|A Biography of Mrs. Marty Mann The First Lady of Alcoholics Anonymous - Brown, David R|
|Methionine Oxidation Perturbs the Structural Core of the Prion Protein and Suggests a Generic Misfolding Pathway*. (Volume 287) - Younan, Nadine D.|
This article is from The Journal of Biological Chemistry, volume 287.AbstractBackground: Oxidation and protein misfolding are fundamental to prion diseases.Results: Oxidation generates a monomeric, helical, and molten globule followed by a β-conformation that lacks a cooperative fold.Conclusion: Oxidation of the prion protein destabilizes its native fold and shares a common misfolding pathway to amyloid fibers.Significance: The misfolding may explain the high levels of oxidized methionine in sc...
|Re-partitioning of Cu and Zn isotopes by modified protein expression. (Volume 9) - Buchl, Anette|
This article is from Geochemical Transactions, volume 9.AbstractCu and Zn have naturally occurring non radioactive isotopes, and their isotopic systematics in a biological context are poorly understood. In this study we used double focussing mass spectroscopy to determine the ratios for these isotopes for the first time in mouse brain. The Cu and Zn isotope ratios for four strains of wild-type mice showed no significant difference (δ65Cu -0.12 to -0.78 permil; δ66Zn -0.23 to -0.48 permil)...
|Amyloid-? and Proinflammatory Cytokines Utilize a Prion Protein-Dependent Pathway to Activate NADPH Oxidase and Induce Cofilin-Actin Rods in Hippocampal Neurons. (Volume 9) - Walsh, Keifer P.|
This article is from PLoS ONE, volume 9.AbstractNeurites of neurons under acute or chronic stress form bundles of filaments (rods) containing 1∶1 cofilin∶actin, which impair transport and synaptic function. Rods contain disulfide cross-linked cofilin and are induced by treatments resulting in oxidative stress. Rods form rapidly (5–30 min) in >80% of cultured hippocampal or cortical neurons treated with excitotoxic levels of glutamate or energy depleted (hypoxia/ischemia or mitochondrial in...